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Varenicline is an efficacious aid to smoking cessation



Varenicline is a nicotine receptor partial agonist. It works both by reducing withdrawal and by blocking the effects of nicotine. Pooled results show varenicline at standard dose more than doubles the chances of successful long-term smoking cessation compared with placebo. Most guidelines recommend it as a first line treatment. Lower dose regimens also appear to confer benefits for cessation, while reducing the incidence of adverse events. The most frequently recorded adverse effect of varenicline are nausea and sleep disruption, but mostly at mild to moderate levels and tending to subside over time. Early reports of possible links to suicidal ideation and behaviour have not been confirmed by current research.



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Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD009329. DOI: 10.1002/14651858.CD009329.pub2.

Cahill K, Stevens S, Perera R, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database of Systematic Reviews . Art. No.:

Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD009329. DOI: 10.1002/14651858.CD009329.pub2.

Anthenelli, Robert M., et al. Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial.

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