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Combining the nicotine patch with an ad libitum type of NRT increases success rates.



Use of the patch to establish a background level of nicotine, combined with using gum, inhaler/inhalator or nasal spray when cravings occur, may provide better control of withdrawal. Most guidelines recommend combined NRT as a first line treatment. There is no evidence that using more than one form is likely to lead to nicotine overdose (see Safety section).



Fiore MC, Jaén CR, Baker TB, et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service. May 2008.

Stead LF, Perera R, Bullen C, Mant D, Hartmann-Boyce J, Cahill K, Lancaster T. Nicotine replacement therapy for smoking cessation. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD000146. DOI: 10.1002/14651858.CD000146.pub4.

Loh WY, Piper ME, Schlam TR, Fiore MC, Smith SS, Jorenby DE, et al. Should all smokers use combination smoking cessation pharmacotherapy? Using novel analytic methods to detect differential treatment effects over 8 weeks of pharmacotherapy. Nicotine & Tobacco Research 2012; 14: 131-41

Brose LS, West R, McDermott MS, Fidler JA, Croghan E, McEwen A. What makes for an effective stop-smoking service? Thorax 2011 66( 10) 924-6

Report of the Committee on Safety of Medicines Working Group on Nicotine Replacement Therapy. Medicine and Healthcare products Regulatory Agency Committee on Safety of Medicines, 2005.

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