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Bupropion and nortriptyline (antidepressants) and varenicline and cytosine (nicotine receptor partial agonists) are cost-effective therapies in smoking cessation programs.



Measured by incremental cost-utility ratios (cost per quality adjusted life-year gained), bupropion was found to be more cost-effective than nicotine gum, when only the direct costs of the intervention were considered. If the effects of smoking cessation on production and consumption in the economy are also taken into account, bupropion is more cost-effective than both forms of NRT tested (nicotine patch and nicotine gum), at a relatively low incremental cost per quality-adjusted life-year gained. 

In the UK, the cost-effectiveness of bupropion for smoking cessation is better than many accepted healthcare interventions. The incremental cost per life year saved is about £640–1,500 (US$ 937 – 2,196) for bupropion and £900–2,000 (US$ 1,318 – 2,928) for NRT plus bupropion.

A meta-analysis comparing the cost-effectiveness of varenicline and bupropion found that varenicline is even more cost-effective.

Among the smoking cessation medications, cytisine and nortriptyline were found globabbly affordable based on World Health Organization criteria since their use can save a life-year for less than or equal to the per-capita gross domestic product in all countries worldwide.



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